REWRITING ORGAN BIOLOGY

PIONEERING GENOME EDITING FOR ORGANS

CasNx lies at the intersection of genome editing and organ transplantation. We are revolutionizing transplant medicine through precise genetic modifications of organs outside the body, creating a new paradigm in personalized solutions that can radically transform patient outcomes.

Technology

Cas1x - Eliminating viruses from donor organs

9 out of 10 donor organs are infected with dangerous latent viruses such as CMV and BKV

Cas1x Platform

We are developing a first of its kind ex-vivo organ antiviral treatment that can clear viruses from donor organs directly on perfusion pump

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Cas2x - Engineering universal donor organs

20% recovered organs are discarded or fail post-transplant because of HLA mismatch

Cas2x Platform

Imagine kidneys, livers, and hearts that bypass immune matching and slash lifelong immunosuppression. Our ex-vivo CRISPR kit deletes immunogenic HLA genes and installs ‘universal donor’ markers while the organ is on perfusion pump.

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Cas3x - Extending donor graft longevity

Upto 40% of kidney grafts fail within 10 years from chronic rejection and injury

Cas3x Platform

We are building an ex-vivo CRISPR cocktail that switches on cytoprotective genes and silences fibrosis drivers in just hours on the pump. Edited organs arrive pre-conditioned to resist shock and double the functional lifespan.

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